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Hydrolyzed collagen
Hydrolyzed collagen characteristics
Hydrolyzed collagen is mainly extracted from the bones and the skin from porcine, bovine and fish origin. The hydrolysis process allows to cut the collagen protein of about 300 000 Da, in small peptides having an average molecular weight comprise between 2000 and 5000 Da.
Amino-acid content
The amino-acid content of hydrolyzed collagen is the same as collagen. Hydrolyzed Collagen contains 20 amino acids, including 8 out of 9 essential amino-acids (there is no tryptophan). It is characterized by the predominance of glycine, proline and hydroxyproline, which represents around 50% of the total amino-acid content. Glycine and proline concentration is 10 to 20 times higher than in other proteins .
Amino-acids
Percentage
Proline/Hydroxyproline
25%
Glycine
20%
Glutamic acid
11%
Arginine
8%
Alanine
8%
Essential amino-acids
16%
Others
12%
Health benefits
Hydrolyzed collagen is a highly digestible protein, and an oral ingestion has been reported as having beneficial effects on joint & bone health, on skin health and for weight management and sports performance.[citation needed]
Digestibility
The bioavailability of hydrolyzed collagen has been demonstrated by many studies. In a study of 1999, scientists demonstrated on mice that more than 90% of orally administered 14C labelled hydrolyzed collagen is digested and absorbed in 6 hours after ingestion. An important part is accumulated in cartilage and skin . In another study of 2005, scientists showed that the hydrolyzed collagen is absorbed in small peptides in the blood .
Skin Health
One preclinical study investigated the effects of oral ingestion of hydrolyzed collagen, along with vitamin C and glucosamine, on the skin properties of women tending to have dry and rough skin. This study suggested that, with the ingestion of 5g per day during 6 weeks, the moisture content of the skin, its viscoelastic properties and its smoothness improved.
Regarding the mechanism of action of hydrolyzed collagen on skin, it seems that orally ingested hydrolyzed collagen increases the density of collagen fibrils and the fibroblasts density (the fibroblasts being the main cells of the dermis, and the ones which produce collagen) . The explanation of this action may be that the peptides of ingested hydrolyzed collagen have chemotactic properties on fibroblasts or an influence on growth of fibroblasts .
Joint & Bone Health
The action of hydrolyzed collagen on joint health is probably the most studied. Many clinical studies report that the oral ingestion of 10g of hydrolyzed collagen by day decreases the joint pain, and that patients having the most severe symptoms benefited more . This beneficial action is probably due to the fact that hydrolyzed collagen is accumulated in cartilage and stimulates the production of collagen by the chondrocytes, the cells of cartilage .
On bone health, several studies have shown that a daily intake of 10g per day of hydrolyzed collagen for 4 to 24 weeks increases bone mass density . It seems that hydrolyzed collagen peptides stimulated the differentiation and the activity of osteoblasts, the cells that build the bone, instead of osteoclasts, those that destroy it.
Nutrition
Hydrolyzed collagen is a good protein to use in blends with others for a weight management diet. It contains 8 out of 9 essential amino-acids, and proteins are recognized as being the most satiating macronutrient . Hydrolyzed collagen is also a good ingredient for a sportive diet. It is important for sportsmen to restore their protein content after an exercise, and the consumption of hydrolyzed collagen that contains more than 97% of protein can help it. Hydrolyzed collagen also contains some glycine and arginine, two of the three amino-acids of the creatine, a molecule which present in the body and having an important play during the exercise, providing energy to the body. Finally, hydrolyzed collagen contains some arginine, which has been shown to be efficient to improve the athletic performance .
Cosmetics
This section does not cite any references or sources.
Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (August 2009)
Hydrolyzed collagen is used in cosmetics for its moisturizing properties.
Uses
When submitted to strict quality controls and sensorial panels , Hydrolyzed collagen may have excellent organoleptic properties, and be taste and odor-free. Due to those properties, it is easy to use in foods and beverages, as well as in powder blends or dietary supplements. Many functional products are already available, especially in Japan. Regarding the cosmetics, hydrolyzed collagen occurs in many products: shampoos, conditioners, soaps, face cares, or even in make-up.
References
^ "What is Hydrolyzed Collagen?". Rousselot. http://www.rousselot-rhc.com/what-is-peptan.html. Retrieved 31 July 2009.
^ a b Oesser, S.; Adam, M., Babel, W. and Seifert, J. (1999). "Oral administration of 14C labelled gelatine hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL)". Journal of nutrition 129: 18911895.
^ Iwai, K.; Hasegawa, T., Taguchi, Y., Morimatsu, F., Sato, K., Nakamura, Y., Higashi, A., Kido, Y., Nakabo, Y. and Ohtsuki, K. (2005). "Identification of food-derived collagen peptides in human blood after oral ingestion of gelatine hydrolysates". Journal of agriculture and food chemistry 53: 65316536.
^ Matsumoto, H.; Ohara, H., Ito, K., Nakamura, Y. and Takahashi, S. (2006). "Clinical effects of fish type I collagen hydrolysate on skin properties". ITE Letters 7(4): 386390.
^ Matsuda, N.; Koyama, Y., Hosaka, Y., Ueda, H., Watanabe, T., Araya, T., Irie, S. and Takehana K. (2006). "Effects of ingestion of collagen peptide on collagen fibrils and glycosaminoglycans in the dermis". Journal of nutrition vitaminology 52: 211215.
^ Postlethwaite, A.E.; Seyer, J.M. and Kang, A.H. (1978). "Chemotactic attraction of human fibroblasts to type I, II, and III collagens and collagen-derived peptides". Proc Natl Acad Sci USA 75(2): 871875.
^ Shigemura, Y.; K Iwai, F Morimatsu, T Iwamoto, T Mori, C Oda, T Taira, EY Park, Y Nakamura and K Sato (2009). "Effect of prolyl-hydroxyproline (Pro-Hyp), a food-derived collagen peptide in human blood, on growth of fibroblasts from mouse skin". J Agric Food Chem 57(2): 444449.
^ Moskowitz, R. (2000). "Role of collagen hydrolysate in bone and joint disease". Seminars in arthritis and rheumatism 30(2): 8799.
^ Ruiz-Benito, P.; Camacho-Zambrano, M.M., Carrillo-Arcentales, J.N., Mestanza-Peralta, M.A., Vallejo-Flores, C.A., Vargas-Lopez, S.V., Villacis-Tamayo, R.A. and Zurita-Gavilanes, L.A. (2009). "A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort". International journal of food science and nutrition 12: 115.
^ Oesser, S.; Seifert, J. (2003). "Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen". Cell tissue research 311: 393399.
^ Nomura, Y.; Oohashi, K., Watanabe, M. and Kasugai (2005). "Increase in bone mineral density through oral administration of shark gelatine to ovariectomized rats". S Nutrition 21: 11201126.
^ a b Wu, J.; Fujioka, M., Sugimoto, K., Mu, G. and Ishimi, Y (2004). "Increase of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats". Bone and mineral metabolism 22: 547553.
^ Bensaid, A.; Tom, D., Leureux-Bourdon, D., Even, P., Gietzen, D., Morens, C., Gaudichon, C., Larue-Achagiotis, C. and Fromentin, G. (2003). "A high-protein diet enhances satiety without conditioned taste aversion in the rat". Physiology and behavior 78: 311320.
^ "Quality Controls". Rousselot. http://www.rousselot-rhc.com/technical-and-quality-datas.html. Retrieved 31 July 2009.
Categories: Dietary supplements | Skin care | Structural proteinsHidden categories: Articles with a promotional tone from August 2009 | All articles with a promotional tone | All articles with unsourced statements | Articles with unsourced statements from November 2009 | Articles needing additional references from August 2009 | All articles needing additional references
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